![]() MajorGeeks download is the 32/64-Bit XP+. Install DOSBox by double clicking the installer file in Windows explorer. Save it in a temporary folder on your hard disk. However, it requires a few code adjustments for the app to function properly. DOSBox-X is a PC emulator that allows users to play DOS games and run applications incompatible with modern PCs and. Download the Windows package (thats the Win32 installer). Seems to work for all games that need it. New The regular 386 core, with prefetch emulation. Curses based debugger allowing some standard debugging features. ![]() Aside from solving compatibility issues, it relies on a simple installation process. Emulating most opcodes now, using libc functions for math functions loses some accuracy (on non x86 hosts). Right-click on the game icon and click Run as. It can also run in both windowed and full-screen mode. (Credit: Alan Bradley) Before turning to third-party solutions, it may be worth trying the built-in Windows options. More than allowing you to launch it on modern computers, the app comes built with enhanced stability thanks to the emulation of the old DOS environment. It also incorporates a few project samples. Download the release for your operating system. Additionally, it comes with code inspection, watches, and tracing features. This guide will use the 0.74 Windows 32-bit version which is available for download. As mentioned, it carries all the features and toolsets of the original Borland app, including a compiler, a debugger, the DOS shell, and breakpoints. Turbo C++ is one of the most reliable alternatives to manually attempting to solve Turbo C++'s incompatibility issues with modern Windows computers. Luckily, there are a few workarounds that you can use. DOSBox is a free program for emulating Disk Operating System (DOS) in Windows and other operating systems. Unfortunately, the program's compatibility with the latest Windows versions is debatable. Software development tools may have surpassed them over the years, but still the Borland app has its uses today. The developer Borland achieved immense success with the release of Turbo and Borland C++, which were, at the time, the most reliable IDE platforms for amateur and professional programmers.
0 Comments
![]() Receive updates on Freshservice incident tickets when the Trello cards linked are moved from the list, so agents stay updated on their status. Track the progress of a Trello card linked to Freshservice incident tickets right from the ticket's page.Ĥ. Keep your IT support team and other Trello teams in sync. Have an Azure support plan associated with your Azure subscription Sign into the Azure portal to submit an incident. ![]() Support is available for Azure subscribers with an Azure Support Plan associated with their subscription. For the purpose of using Trello as a ticket management system you will need to ensure that the following fields are connected in the mapping menu: Title, Ticket Number, Status, Priority, Type, Customer and Description. Be able to select labels, assign members and set up a due date for your new Trello card.ģ. Technical support Azure subscribers can create and manage support requests in the Azure portal. The goal is to enable flawless communication. Create a new Trello card directly from a Freshservice incident ticket, indicating a description of what's needed, requesters name, the status and priority for the Trello teams to be in sync. The Trello app works with the Freshdesk platform providing an easy way to synchronize tickets with Trello boards. Link an existing Trello card to a Freshservice incident ticket.Ģ. support Documentation Plans & pricing What. Follow New articles New articles and comments Setting Up the Trello. ![]() Microsoft LogicApps Support Microsoft Power Automate Support Microsoft Power. Review large diffs with ease, view third-party code reports, and open Jira tickets right from the PR screen. Roadmunk Integrating Tools Trello Integration. Your service desk team will collaborate instantly and effortlessly by linking Trello cards + Freshservice tickets.ġ. Trello gives you perspective over all your. Organize your workflow in Trello or boost collaboration with other teams, taking into account tickets' priority to deliver exceptional support according to the company's needs. Improve your IT service team's performance by empowering them to send their tickets to Trello cards. Insert and create tickets into Trello cards. Empower your IT team to solve your company's needs faster. Bring your teams together to deliver exceptional customer support with a Freshservice and Trello power-up. This two-way integration requires you to download our Freshservice Power-Up in your Trello boards to be able to view Freshservice tickets directly from linked Trello cards and more. Discover how to attach Dropbox files and folders to Trello cards, generate shared links to files and preview files with the Trello integration for Dropbox. ![]() Iberdrola – $39.79bn Iberdrola’s net profit grew by 7.5% to $3.4bn in 2018. The GE Renewable Energy segment provides onshore and offshore wind turbines and blades, as well as hydropower solutions. The GE Power segment provides products and services related to energy production, while the GE Lighting segment develops lighting solutions. ![]() Revenue from its renewable energy segment, however, increased by 4% during the year. The company’s revenue from the power segment decreased by 22%, whereas that from the lighting business dropped by 11%. The three segments respectively contributed $27.3bn, $9.53bn, and $1.7bn to the company. General Electric’s (GE) three energy segments Power, Renewable Energy, and Lighting generated $38.5bn in revenues, accounting for 31.7% of the company’s total revenue of $121.6bn during the year. General Electric Co – $38.5bn General Electric’s (GE) Power, Renewable Energy and Lighting segments contributed $38.5bn revenues in 2018. Siemens Gamesa Renewable Energy, which is engaged in the wind power business, reported a 5% decrease in revenue, but an 8% increase in orders. The Energy Management segment engaged in the supply of power transmission and distribution products, reported a 5% increase in revenue, but a 10% decrease in orders. The Power and Gas segment, which provides products and solutions for the operation of fossil fuel and renewable power plants, witnessed a 14% decrease, while the total orders in this segment increased by 14%. Siemens’ energy segments, including Power and Gas, Energy Management, and Siemens Gamesa Renewable Energy, contributed $14.13bn, $13.93bn, and $10.36bn respectively to its total consolidated revenue of $94.35bn in 2018. Siemens – $38.42bn Siemens’ Power and Gas segment generated $14.13bn in revenue in 2018. The European Commission (EC) approved the acquisition of E.ON and Innogy’s renewable businesses by RWE in February 2019. It also operates a nuclear power business in Germany through PreussenElektra. The company’s Non-Core Business accounted for 4% of the total revenue.Į.ON operates more than 5GW of renewable power plants worldwide. Its Energy Networks segment accounted for 29.5% of the total revenue during the period, followed by Customer Solutions 20%, and the Renewable segment 3.3%. Germany-based, privately owned international energy company E.ON’s revenues for the year ending September 2018 stood at $36.93bn. E.ON – $36.93bn E.ON’s revenue for the year ending September 2018 was estimated at $36.93bn. ![]() ![]() She wears a blue attire similar to a cheerleader costume with cat-paw gloves, a blue-striped cat-tail, a headgear and a pair of transparent goggles. She has long blonde hair with long strands of bangs falling over the right side of her face fetchingly. Pixie Bob is one of the sexiest My Hero Academia female characters. Her Quirk Earth Flow allows her to manipulate the earth to whatever effect as she wishes. Next on the list is Mandalay’s Wild, Wild Pussycats teammate, Pixie Bob or Ryuko Tsuchikawa. She has bobbed burgundy-red hair and wears red paints on her face with her hero costume. She is the aunt of Kota Izumi whose Pro Hero parents were killed by Muscular.Ī pretty lady to look at, Mandalay is also very kind and efficient. Mandalay is a Pro Hero, operating in a team called Wild, Wild Pussycats. Her hero costume is pretty simple along with black thigh-highs and a mask similar to Bakugo’s. She has green flaming hair that she can pull off to throw as a fireball. Like our previous entry, Burnin’s looks are also affected by her Quirk. She’s part of the team Flaming Sidekickers and has often bicker with Bakugo. Burnin or Moe Kamiji is one of Endeavor’s sidekicks. No woman on this list is as hot as Burnin, literally. This pretty woman is number 20 on this list of sexiest My Hero Academia female characters. Her eyes are green but her sclera is black, similar to Mina’s. ![]() She worked as an executive director at Shoowaysha Publishing Company and secretly a member of the Meta Liberation Army.Īn incredibly sexy woman, Curious has stylish lilac hair that compliments her pale blue skin. Many characters look extraordinary because of their Quirks and Chitose Kizuki aka Curious is one of them. My Hero Academia has a diverse cast when it comes to appearances. ![]() She wears a sexy blue bodysuit and high boots as her hero costume. She has long blonde hair with a brown patch at the top of her head. Clair Voyance is a Pro Hero and one of Endeavor’s many sidekicks.Ĭlair Voyance is a tall and beautiful woman who deserves the 21st spot on our list of sexiest My Hero Academia female characters. She appears in the latest My Hero Academia movie, World Heroes’ Mission. 21) Clair VoyanceĬlair Voyance is another movie character. The gorgeous woman also wears cowboy boots and a cowboy hat to complete her look. She wears a cowgirl outfit as her hero costume, consisting of an orange crop-top with denim shorts and sleeveless denim jacket. They witnessed All Might stopping two robbers during the time young All Might was studying in America.Ĭow Lady is very hot, with her wavy blonde hair and bright blue eyes. 22) Cow LadyĬow Lady is an American Pro Hero that appeared on My Hero Academia: Two Heroes. She also wears purple thigh-highs with black boots and a black mask. Slice wears a stylish outfit of lavender shirt under a tight navy blue dress. She can harden and regrow her hair to use as a sharp slicer. Slice is a fair and lean woman with long, dark red hair. Her villain name is Slice which is also the name of her Quirk. She was a part of Nine’s team and acted as an antagonist. Slice appeared in the movie, My Hero Academia: Heroes Rising. Her hero costume is a sailor uniform with white gloves and thigh-high stockings. She has sky blue hair and blue eyes but her most prominent features are her large fin-like ears. Sirius’ appearance is modified by her Quirk. ![]() Even though this app is more likely to recall and visually portrayed, it allows consumers to work swiftly and effectively while saving a great deal of time on information collection and communication. Users with a valid license for Mindjet MindManager can better organize their ideas and prioritize their work thanks to the program’s intuitive interface. Foreign-trade themes for Microsoft Word and PowerPoint, designed by MindManager Full Crack 2023. Customers using Mac computers and Mind View are more productive overall. By keeping a MindManager recording of your gatherings, you can rest assured that all of the fundamental ideas discussed will be captured and made available for subsequent action items. Using Mindjet MindManager Serial Key maps in meetings increases participation since participants can see you adding information, priority indicators, and other details as the conversation progresses. To better organize and keep track of your tasks, use the drag-and-drop interface. Does Downloading Mindjet MindManager Enable Users to Seize Ideas?ĭownloading Mindjet MindManager enables you to seize ideas, create effective strategies, and manage any situation. Even though each graphic can be viewed in several distinct variations, you should already be focusing on multiple tasks at once. Whether users are making a business plan or a web app, strong representations give them all the tools they need to handle and complete every task. Their one-of-a-kind efficiency is boosted by the Macintosh version of the visual thinker’s programmer fracture. If you use a personal computer and want to keep track of everything you do, this is the organizer for you. ![]() With Mindjet MindManager 2023 Crack, your team will be able to handle more work in less time. Personal computer Thought Picture users tend to have a more positive experience overall. As users log sessions in this app, they can rest certain that their most important ideas will be safely stored and readily accessible for obey in engagement areas. ![]() As the conversation continues, the customer might be able to immediately see how you are mixing information, and prioritizing hints, and Components. The aforementioned program, Fracture, includes Microsoft’s foreign business templates. How Does Mindjet MindManager 2023 Crack Work? MindManager Full Crack 2023 includes Microsoft Word and PowerPoint templates with an international commercial theme. It’s a Windows computer inside a Mac Users of Mind View enjoy increased efficiency throughout their whole workflow. With MindManager’s meeting recording features, you can rest easy knowing that all of the meeting’s most important ideas will be captured and made easily accessible through the use of activity points. Using Mindjet MindManager Serial Keymaps in meetings allows everyone to see how you’ve incorporated ideas, priorities, and other information into the discussion in real-time. You can choose to share your ideas on the strategy, and serial keys will help you get things done. The ability to drag and drop tasks and responsibilities greatly facilitates their management and organization. The Mindjet MindManager Download can be used for note-taking, organizing, and planning. With the help of this app, you may get your thoughts in order and zero in on the most crucial components of a project. What is the Use of the Mindjet MindManager Serial Key Crack? Data can be imported, modified, and managed within this application system, as well as communicated within it. Information entered into a business app can be routed to the selected app automatically. Each member of the group can benefit from the group’s marketing efforts. It can be used for information gathering and presenting purposes including organizing a meeting, drafting a white paper, or making an outline for a presentation. Mindjet MindManager 2021 v21.0.261 (圆4) Final + Crack.zip (328.The full version of Mindjet MindManager is also available, which facilitates collaborative and efficient work by reducing the time spent on information gathering and dissemination. MindManager lets your brain work with information the way it was designed to - fast & dynamically - so you don’t lose a single brilliant insight or critical detail. Rigid, linear tools can leave your best thinking on the table.Make your maps communicate exactly what you need, with new capabilities like Timeline layout, more powerful filtering, easier navigation and walk-through mode.With improved HTML5 export, you can easily share your maps and create alignment with just about anyone - on your team, in your org and beyond.Built-in sync with the tools you use every day, plus available integration with 800+ apps, gives you one-stop access to all the information that matters. ![]() MindManager puts you in command of the information surrounding your work, business and world - instead of controlled, confused or overwhelmed by it. MindManager makes it easier to think, plan, and communicate. ![]() You can snooze both read and unread messages. After the selected time Gmail will inform you again about the message as it would about any other new email. It allows you to postpone emails for a chosen period of time. Snoozing messages is one of the latest Gmail features. To stop ignoring a given thread, find it in the “All mail” section and select “Move to inbox” If you need to check on the message or see how the conversation developed – you can find it by browsing the “All mail” section or using the search bar. ![]() It is especially useful when other users reply to messages in a thread that is not relevant to us. In both cases, however, the messages are stored in the “all” section. This is the main difference between mute and archive functions. Each message will be automatically archived without any notifications. You can silence the thread by selecting it and clicking “Mute”Īfter muting a message, no new correspondence from the thread will be shown in the inbox. This is one of the oldest functions of Gmail. Muting a message is a subtle way to ignore notifications from a conversation without notifying the sender. To undo archiving, go to the “All” label and select the desired message. If you do not want to delete a message and do not need it in the main view, then archive it. The “archive” function is useful, for example, when cleaning the inbox. They are available under the label “All Mail” When should you use it? As nifty as many of Mailbox’s features were/are, it was only a matter of time before the big guys got around to copying all of the best bits they could manage.Unfortunately, there is no dedicated section for archived emails. This sort of thing is why it was quite good that Mailbox sold when they did. It’d also be particularly handy for emails you know you’ll need to reference frequently, like one with an important address in it. ![]() (Note the pin icons next to individual emails in the screenshot above.) If “snoozing” is like hitting the snooze button on your alarm, pinning is letting the alarm blare in your face until you eventually get out of bed. Email pinning, to force an email to stick to the top of your inbox until you decide to unpin it.In addition to the Social/Promotion/Forum/Updates tabs already found in Gmail, they’re purportedly dabbling with tabs for Travel, Purchases (order confirmations, receipts), and Finance (banking stuff). Now, it seems, Gmail wants in on the snoozin’.Īccording to, Google is testing a build of Gmail with a bunch of neat new tricks packed in, email snoozing included.Īlso in testing, according to the report: You’d still answer it… if you hadn’t totally forgotten about it.īack when Mailbox (now owned by Dropbox) launched in January 2013, their solution to this - the ability to “snooze” an email to have it resurface at the top of your inbox - was one of its most exciting features. ![]() “I’ll answer this tomorrow,” you tell yourself.īy tomorrow, the email has dropped down to the bottom of your inbox, replaced by 100 way less important things. Not like, oh-god-drop-everything-or-we’ll-all-die important, but it’s something you should probably answer.īut you’ve got stuff to do right now, so you don’t. The better the preparation and design, the better the outcomeįees. Another delicate high-strung wire to tread. We don’t do this every year, checking what’s hot and what’s not, we’re investing our organisation’s money and reputation in being both relevant and bold. The rejection of even the idea of ‘corporate’ is wholesale, so everything must be its antithesis.īut it has to last. Our workplace has to chime with their expectation of an organisation on a mission. We’re looking for the emerging talent, those in-tune with the zeitgeist, the innovators of today and leaders of tomorrow. ![]() We don’t want to be left behind, left out. While they don’t set the pulse racing, they exude confidence. Here resides everything we consider to be classic, the aesthetic, features and elements that never tire. Then there’s the slow wave beneath reassuring, easy, reliable and assured. Workshop chic with its crumbling plaster, exposed brick, eye-straining filament lightbulbs and sagging felt. Pushing up our jacket sleeves, turning over our collar. The occasional re-emergence and rapid disappearance of bell-bottoms. In this channel live the forms and tastes of the moment. There’s the frenetic day-to-day we can barely keep up with, our packed schedules, projects, initiatives, ideas, all battling with the demands of our personal lives. We want our fit-out to last (longer than flares) DON’T let fad and fashion dictate the outcome The things in the present that are working that we can do more of, together with a crafted vision of the future incorporating the changes we want to prompt and enable.īalance doesn’t come easy. It’s easy to fall into either trap, but it’s about balance. But if we create a space for what we have today, what changes? We want to make sure we reflect their needs in the new workplace, and we want them on board with the outcome. But how much? We’ve studied and modelled how we work, with different groups and teams doing different things in different ways. Like our pre-lockdown favourite jeans, the present just doesn’t fit anymore. ![]() We want some of that, to be a leader, out there, shaping the future. ![]() We’ve studied the trends, looked at what our competitors are doing, marvelled at what the seriously cool companies are doing. DON’T consider the present at the expense of the future – and the future at the expense of the present From brief to delivery, each week we will share with you his Top 10 Tips. We asked Neil Usher – Chief workplace & Change Strategist at GoSpace AI and author of The Elemental Workplace and Elemental Change – what he considered to be the 10 key things not to do in creating a new workplace. For many of us, we don’t do these projects very often, so we need some helpful guidance. The decisions we take, the things we do and the things we miss. While we like to think that problems we may encounter will all be the result of forces beyond our control, we’re just as likely to be the reason. You’ve secured the funds and know you can create your new workspace in time. ![]() Those who would consider switching from Creative Cloud can probably figure out how to accomplish their necessary tasks using the Affinity apps. ![]() Serif’s StudioLink technology provides direct access to the primary tools from Affinity Photo and Affinity Designer right within an Affinity Publisher document. And some may not exist at all-it doesn’t seem that Affinity Publisher (the newest addition to the suite) has a Track Changes feature like InDesign.įor instance, just as you can embed Photoshop and Illustrator files in an InDesign layout and then use the Edit Original command to edit them in the other app, you can embed Affinity Photo and Affinity Designer files in Affinity Publisher. Others may even be better-some people we know find exporting Web graphics from Affinity Designer easier than exporting from Illustrator. ![]() Some may not match up-we’ve been told that master pages in Affinity Publisher are a bit funkier than master pages in InDesign, for instance. We can’t answer that for sure-the Adobe apps have so many features that it’s impossible to know which are most important to you and if the Affinity apps’ features are comparable. The obvious question is if you could replace Photoshop, Illustrator, and InDesign with Affinity Photo, Affinity Designer, and Affinity Publisher. Versions for Microsoft Windows are available for $55 too, and Affinity Photo and Affinity Designer also come as $10 iPad apps. That’s right, you can buy all three for $165, or just about the same as 3 months of Creative Cloud. However, if you’re subscribing to Adobe Creative Cloud merely because you need a capable image editor, illustration app, or page layout package, and you aren’t otherwise deep in the Adobe ecosystem, consider the Affinity suite from Serif: Affinity Photo, Affinity Designer, and Affinity Publisher, each of which costs $55. If you fall into that camp, no worries, and you can stop reading right now. They need the full power of Adobe’s tools, and they need to collaborate with others using native Photoshop, Illustrator, and InDesign files. That All Apps bundle works out to an eye-watering $636 per year.įor many people, that $636 annual expense is just the cost of doing business. Adobe provides access to them only via Creative Cloud subscriptions, where each app costs $21 per month, making it hard to pass up the $53-per-month All Apps bundle that includes all three plus Premiere Pro, Acrobat Pro, and more. Many design and publishing professionals spend their lives in one or more of these apps. Few would disagree that the most popular image editing software in the world is Adobe Photoshop, the top illustration app is Adobe Illustrator, and the preeminent page layout package is Adobe InDesign. The lyrics to the song " Jingle Bells" used footage from the 1949 Famous Studios Screen Song cartoon " Snow Foolin'", which was also in the public domain. ![]() This is due to the cartoon being in the public domain, allowing Disney to use it without any legal trouble. The song " Rudolph the Red-Nosed Reindeer" used footage from the 1948 Max Fleischer cartoon of the same name, as Disney has never made their own Rudolph cartoon.The VHS cover features artwork of Mickey and friends caroling, which was reused for the 2005 DVD release of Walt Disney's Classic Cartoon Favorites Volume 9: Classic Holiday Stories." From All of Us to All of You" is played at the end of the advanced level of the Words of the Season vocabulary game on the 2002 DVD release.The firework shot from " A Present for Donald" is used at the end, as well. In the original issues, a still image of the Christmas tree from the animated film Lady and the Tramp is used for the closing credits." The Best Christmas of All" (from Mickey's Magical Christmas: Snowed in at the House of Mouse) Mickey Mouse Works: "Mickey's Christmas Chaos" Mickey Mouse Works: " Mickey's Mixed Nuts" " White Christmas" (Bing Crosby's version) " Rockin' Around the Christmas Tree" (Brenda Lee's version) Mickey's Magical Christmas: Snowed in at the House of Mouse Mickey Mouse Works: " Mickey's Christmas Chaos"īeauty and the Beast: Belle's Magical World " Jingle Bell Rock" (Bobby Helms' version) " As Long As There's Christmas" (from Beauty and the Beast: The Enchanted Christmas)īeauty and the Beast: The Enchanted Christmas " Seasons of Giving" (from Winnie the Pooh: Seasons of Giving) " All I Want for Christmas is My Two Front Teeth" (sung by Goofy and Max (he is portrayed with a lisp)) " Toyland" (from Babes in Toyland (sung by an unidentified children's chorus)) " Winnie the Pooh's Jingle Bells" (from Winnie the Pooh: A Very Merry Pooh Year) " It's Beginning to Look a Lot Like Christmas" (singer unknown) The 2002 reissue removed " From All of Us to All of You" from the actual program and added in the following songs: Plays over the closing credits during Lady and the Tramp background and the fireworks ending from " A Present for Donald" on the 1988, 19 releases. " We Wish You a Merry Christmas" (sung by the Disneyland Sing-Along Chorus (Larry Groce is credited too)) Night on Bald Mountain/Ave Maria ( Fantasia) " Silent Night" (sung by the Living Voices) " Rudolph the Red-Nosed Reindeer" (sung by Gene Autry) " Here Comes Santa Claus" (sung by Larry Groce, the Disneyland Sing-Along Chorus, with Mickey, Donald, and Goofy) " Winter Wonderland" (sung by Larry Groce and the Disneyland Sing-Along Chorus (only the chorus is credited)) ![]() " Parade of the Wooden Soldiers" (sung by Don Janse's Children's Chorus) " Sleigh Ride" (sung by Larry Groce and the Disneyland Sing-Along Chorus with Mickey Mouse, Donald Duck and Goofy) The Cold-Blooded Penguin ( The Three Caballeros) The Wind in the Willows ( The Adventures of Ichabod and Mr. " Let it Snow, Let it Snow, Let it Snow" (sung by Bing Crosby) " Up on the Housetop" (sung by Don Janse's Children's Chorus) " Joy to the World" (sung by Larry Groce and the Disneyland Sing-Along Chorus) " Jingle Bells" (sung by the Disneyland Sing-Along Chorus) " Deck the Halls" (sung by the Disneyland Sing-Along Chorus (Larry Groce is credited too)) Walt Disney Presents: " From All of Us to All of You" (colorized version) " From All of Us to All of You" (new lyrics sung by Eddie Carroll as Jiminy Cricket) The original 1988, 19 VHS releases contained the following songs: Gather up the family and enjoy a fun-filled collection of the most beloved Christmas songs and carols, accompanied by a wonderland of wintry holiday scenes! It's a kaleidoscope of sights and sounds that is sure to make everyone's holiday very, very merry! Voices ready? Let's all sing! Songs It's the happiest time of the year! And the season of Santa, reindeer and gift-wrapped surprises will be even jollier with this joyful volume of Disney's Sing-Along Songs: Very Merry Christmas Songs. ![]() These consistent cross-site findings highlight the homogeneity of this single genetic etiology, and support the suitability of 22q11DS as a biological model of schizophrenia. Psychotic illness in this highly penetrant deletion was associated with similar neuroanatomic abnormalities to idiopathic schizophrenia. We found a robust neuroanatomic signature of 22q11DS, and the first evidence that deletion size impacts brain structure. Finally, cortical SA was significantly greater in 22q11DS cases with smaller 1.5 Mb deletions, relative to those with typical 3 Mb deletions. Comparison of 22q11DS-psychosis to idiopathic schizophrenia (ENIGMA-Schizophrenia Working Group) revealed significant convergence of affected brain regions, particularly in fronto-temporal cortex. controls were classified with 93.8% accuracy based on these neuroanatomic patterns. Cortical surface area (SA), however, showed pervasive reductions in 22q11DS (left/right hemispheres: d = −1.01/−1.02). Compared to controls, 22q11DS individuals showed thicker cortical gray matter overall (left/right hemispheres: Cohen’s d = 0.61/0.65), but focal thickness reduction in temporal and cingulate cortex. The imaging data were collected from 10 centers worldwide, including 474 subjects with 22q11DS (age = 18.2 ± 8.6 46.9% female) and 315 typically developing, matched controls (age = 18.0 ± 9.2 45.9% female). To address these issues, we developed the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta-Analysis) 22q11.2 Working Group, representing the largest analysis of brain structural alterations in 22q11DS to date. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpowered to characterize neuroanatomic abnormalities associated with psychosis in 22q11DS, and/or neuroanatomic effects of variability in deletion size. The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. McDonald-McGinn, 28, 29, 30 Beverly Emanuel, 29, 30 Theo G. Butcher, 16, 18 Fidel Vila-Rodriguez, 25 Joanne Doherty, 26 Adam Cunningham, 26 Marianne B.M. Murphy, 13, 14 Declan Murphy, 13, 14 Michael Craig, 13, 15 Jacob Vorstman, 16, 17, 19 Ania Fiksinski, 16, 18, 19, 20, 21 Sanne Koops, 17 Kosha Ruparel, 22 David R. McCabe, 11, 23 Eileen Daly, 13 Maria Gudbrandsen, 13 Clodagh M. Jonas, 1, 4 Therese van Amelsvoort, 7 Geor Bakker, 7 Wendy R. Villalon-Reina, 3 Xiaoping Qu, 3 Rachel K. Forsyth, 1, 5 Leila Kushan, 1 Ariana Vajdi, 1 Maria Jalbrzikowski, 6 Laura Hansen, 1 Julio E. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |